The apolipoprotein E e4 allele is well known for its association with amyloid deposition in Alzheimer’s disease, but now it also appears to help drive the other key pathological process in the disease: deposition of hyperphosphorylated tau protein. This PET neuroimaging study was authored by senior investigator Gil Rabinovici, MD, a neurologist and professor of memory and aging at the University of California, San Francisco and presented at the 2017 American Neurological Association Annual Meeting.
Read the Clinical Neurology News article about the study: APOE4 may drive tau deposition in Alzheimer’s